That loud twanging noise you're going to hear Friday evening and Saturday is the sound of a waning Moon in Pisces tripping over the North Node, Uranus, and Mars all in short order... squaring Jupiter at first and finishing off with a square to Pluto.
Put another way, excess and a change of pace could lead to explosive results. "Explosive results" are exactly what's called for if you have any emotional mountains to move. Of course, if you don't... you might want to think about just staying home and renting a DVD. Otherwise, someone might try to move your mountain for you. Who wants to do that much heavy lifting on the weekend if you don't have to?
Speaking of "heavy lifting", this particular combination can be bad for sprains and muscle strains. Remember: lift from the knees...
This advice particularly applies if you have any major placements near the end of the mutable signs, and/or if your birth day is March 17-22, June 18-23, September 19-24, or December 18-23.
If you don't know the details of your birth chart, ask an astrologer.